Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate).

Abstract

A series of phenyl-substituted derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) (1) were synthesized and tested for antileukemic activity against P388 lymphocytic leukemia in the mouse. All of the compounds tested, 1a--r, showed significant activity in this assay. Selected derivatives of 1 were tested against several bacteria and were found to have little or no antibacterial activity in the systems examined.

• Authors: W K Anderson, M J Halat
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 22 Issue 8 Pg. 977-80 (Aug 1979) ISSN: 0022-2623 [Print] United States
• PMID: 490542 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Carbamates
• Pyrroles

Topics

• Animals
• Antineoplastic Agents (chemical synthesis)
• Bacteria (drug effects)
• Carbamates (chemical synthesis, pharmacology)
• Chemical Phenomena
• Chemistry
• Leukemia P388 (drug therapy)
• Mice
• Pyrroles (chemical synthesis, pharmacology)