Chromosome breaking activity of human feces and its enhancement by transition metals.

Abstract

Chloroform-methanol extracts from human fecal samples were found to contain compounds which induce chromosome aberrations in Chinese hamster ovary cells. The induction of chromosome aberrations is stimulated by Cu2+ or Mn2+ and inhibited by Fe2+ or Fe3+. Addition of catalase to the fecal extract or the mixture of fecal extract and Mn2+ reduced the frequency of chromosome aberrations. These properties are indicative of hydroxyradical producing agents.

• Authors: H F Stich, U Kuhnlein
• Journal: International journal of cancer (Int J Cancer) Vol. 24 Issue 3 Pg. 284-7 (Sep 15 1979) ISSN: 0020-7136 [Print] United States
• PMID: 489168 (Publication Type: Journal Article)

Chemical References

• Metals
• Mutagens
• Copper
• Chloroform
• Iron
• Catalase
• Magnesium
• Methanol

Topics

• Animals
• Catalase (pharmacology)
• Cells, Cultured
• Chloroform
• Chromosome Aberrations
• Copper (pharmacology)
• Cricetinae
• Feces (analysis)
• Female
• Humans
• Iron (pharmacology)
• Magnesium (pharmacology)
• Metals (pharmacology)
• Metaphase (drug effects)
• Methanol
• Mutagens (isolation & purification)
• Ovary (cytology)