Abstract |
Three hundred patients with grass pollen hay-fever, with or without pollen asthma, were given one of three forms of treatment: preseasonal or coseasonal alum-precipitated pyridine extracted grass pollen ( Allpyral) or methylprednisolone acetate in slow-release form ( Depo-Medrone). Significant improvement was obtained with preseasonal Allpyral and with Depo-Medrone, but the degree of improvement obtained with coseasonal Allpyral fell within the limits of placebo response.Nevertheless, it is considered that the definite suppression of the pituitary-adrenal function which results from the use of a long-term steroid is not justified in a benign condition such as hay-fever.
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Authors | M A Ganderton, J Brostoff, A W Frankland |
Journal | British medical journal
(Br Med J)
Vol. 1
Issue 5640
Pg. 357-8
(Feb 08 1969)
ISSN: 0007-1447 [Print] England |
PMID | 4883848
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Pyridines
- Methylprednisolone
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Topics |
- Asthma
(drug therapy)
- Clinical Trials as Topic
- Delayed-Action Preparations
- Humans
- Methylprednisolone
(administration & dosage, therapeutic use)
- Poaceae
- Pollen
- Pyridines
(administration & dosage, adverse effects, therapeutic use)
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Seasons
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