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Comparison of preseasonal and coseasonal Allpyral with Depo-Medrone in summer hay-fever.

Abstract
Three hundred patients with grass pollen hay-fever, with or without pollen asthma, were given one of three forms of treatment: preseasonal or coseasonal alum-precipitated pyridine extracted grass pollen (Allpyral) or methylprednisolone acetate in slow-release form (Depo-Medrone). Significant improvement was obtained with preseasonal Allpyral and with Depo-Medrone, but the degree of improvement obtained with coseasonal Allpyral fell within the limits of placebo response.Nevertheless, it is considered that the definite suppression of the pituitary-adrenal function which results from the use of a long-term steroid is not justified in a benign condition such as hay-fever.
AuthorsM A Ganderton, J Brostoff, A W Frankland
JournalBritish medical journal (Br Med J) Vol. 1 Issue 5640 Pg. 357-8 (Feb 08 1969) ISSN: 0007-1447 [Print] England
PMID4883848 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Pyridines
  • Methylprednisolone
Topics
  • Asthma (drug therapy)
  • Clinical Trials as Topic
  • Delayed-Action Preparations
  • Humans
  • Methylprednisolone (administration & dosage, therapeutic use)
  • Poaceae
  • Pollen
  • Pyridines (administration & dosage, adverse effects, therapeutic use)
  • Rhinitis, Allergic, Seasonal (drug therapy)
  • Seasons

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