The influence of 2,2-dimethyl-1-(4-methylphenyl)-1-propanone (SaH 50-283) on food efficiency in rats.

Abstract

The present studies were undertaken to investigate the possible mechanism(s) of action of 2,2-dimethyl-1-(4-methylphenyl)-1-propanone (SaH 50-283) on food efficiency in rats. SaH 50-283, unlike phenformin (DBI), did not inhibit glucose absorption. However, hyperglycemia induced by oral maltose, lactose or starch load was markedly inhibited in animals pretreated with SaH 50-283. The ED25 for lowering blood sugar levels following an oral maltose load was calculated to be 12 mg/kg. SaH 50-283 could be administered as long as 7 hr prior to a maltose load and still maintain its effect. Food efficiency was significantly (P less than .01) lowered in rats pretreated with SaH 50-283 1 hr prior to a 2 hr feeding period of a purified high carbohydrate diet. It was concluded that the lowering of maltase activity in the brush border of animals treated with SaH 50-283 could partially account for its mechanism of action in lowering food efficiency in rats.

• Authors: R S Ho, C G Aranda
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 237 Issue 1 Pg. 98-109 (Jan 1979) ISSN: 0003-9780 [Print] Belgium
• PMID: 485687 (Publication Type: Journal Article)

Chemical References

• Dietary Carbohydrates
• Insulin
• Ketones
• Liver Glycogen
• Maltose
• Glucose

Topics

• Animals
• Dietary Carbohydrates (metabolism)
• Food
• Glucose (metabolism)
• Glucose Tolerance Test
• Insulin (pharmacology)
• Intestinal Absorption (drug effects)
• Ketones (pharmacology)
• Lipid Metabolism
• Liver (metabolism)
• Liver Glycogen (metabolism)
• Male
• Maltose (metabolism)
• Metabolism (drug effects)
• Microvilli (metabolism)
• Rats