Abstract |
Several 5-alkyl derivatives of 1-beta-d-arabinofuranosyluracil (araU) were tested for antiherpesviral activity and inhibitory action on cell growth in human embryonic lung fibroblasts. 1-beta-d-Arabinofuranosylcytosine, 9-beta-d-arabinofuranosyladenine, and 5-iododeoxyuridine ( IUdR) were included as reference materials. Among the 5-alkyl derivatives of araU, arabinosylthymine was the most active, followed by 5-ethyl- and 5-propyl-araU. 5-Ethyl-araU was as active as IUdR and more active than 9-beta-d-arabinofuranosyladenine against herpes simplex virus (HSV) type 1 and did not inhibit cell growth at a concentration as high as 1,000 mug/ml. 5-Butyl- and 5-methoxymethyl-araU, as well as araU, exhibited relatively low activity. The araU derivatives tested were as active against HSV WT-34, an isolate from a patient with keratitis, as against HSV type 1. Against an IUdR-resistant isolate, HSV WT-20, arabinosylthymine was less inhibitory than IUdR. Deoxyribonucleic acid synthesis in HSV type 1-infected cells was markedly inhibited by arabinosylthymine, IUdR, and 5-ethyl-araU, whereas cellular deoxyribonucleic acid synthesis in uninfected cells was significantly inhibited by IUdR but not by arabinosylthymine or 5-ethyl-araU.
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Authors | H Machida, S Sakata, A Kuninaka, H Yoshino, C Nakayama, M Saneyoshi |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 16
Issue 2
Pg. 158-63
(Aug 1979)
ISSN: 0066-4804 [Print] United States |
PMID | 485126
(Publication Type: Journal Article)
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Chemical References |
- Arabinofuranosyluracil
- DNA
- Thymidine
- Uridine
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Topics |
- Arabinofuranosyluracil
(analogs & derivatives, pharmacology)
- Cell Division
(drug effects)
- Cytopathogenic Effect, Viral
(drug effects)
- DNA
(biosynthesis)
- Herpes Simplex
(drug therapy)
- Thymidine
(metabolism)
- Uridine
(analogs & derivatives)
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