Rubber solvent: a clastogenic agent that fails to induce sister-chromatid exchanges.

Abstract

Rubber solvent was tested for its ability to induce chromosome aberrations and sister-chromatid exchanges in human whole blood cultures. Following exposure to relatively low rubber solvent concentrations (0.0125% and greater) significant increases in the frequencies of chromatid gaps and breaks were observed. At higher rubber-solvent concentrations (0.05% and greater) there were also significant increases in the frequency of chromosome breaks. In contrast to the increase in chromosome aberrations following rubber-solvent exposure, rubber-solvent concentrations up to the toxic level failed to produce increases in the sister-chromatid exchange frequency.

• Authors: L C Altenburg, J H Ray, C E Smart, F B Moore
• Journal: Mutation research (Mutat Res) Vol. 67 Issue 4 Pg. 331-41 (Aug 1979) ISSN: 0027-5107 [Print] Netherlands
• PMID: 481458 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hydrocarbons
• Mutagens
• Petroleum
• Solvents
• rubber solvent
• Rubber

Topics

• Cells, Cultured
• Chromatids (drug effects)
• Chromosome Aberrations
• Chromosomes, Human (drug effects)
• Crossing Over, Genetic
• Drug Evaluation, Preclinical
• Humans
• Hydrocarbons (pharmacology)
• Lymphocytes (ultrastructure)
• Mutagens
• Petroleum
• Rubber
• Solvents (pharmacology)