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Alpha-(N)-formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity.

AuthorsF A French, E J Blanz Jr, S C Shaddix, R W Brockman
JournalJournal of medicinal chemistry (J Med Chem) Vol. 17 Issue 2 Pg. 172-81 (Feb 1974) ISSN: 0022-2623 [Print] United States
PMID4809253 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Heterocyclic Compounds
  • Ribonucleotides
  • Thiosemicarbazones
  • Formaldehyde
  • Alcohol Oxidoreductases
Topics
  • Alcohol Oxidoreductases (antagonists & inhibitors)
  • Animals
  • Antineoplastic Agents (chemical synthesis, therapeutic use)
  • Carcinoma (drug therapy)
  • Cell Line
  • Dose-Response Relationship, Drug
  • Formaldehyde (chemical synthesis, therapeutic use)
  • Heterocyclic Compounds (chemical synthesis, therapeutic use)
  • Humans
  • Laryngeal Neoplasms
  • Leukemia L1210 (drug therapy)
  • Lung Neoplasms (drug therapy)
  • Mice
  • Neoplasms, Experimental (drug therapy)
  • Ribonucleotides
  • Sarcoma 180 (drug therapy)
  • Structure-Activity Relationship
  • Thiosemicarbazones (chemical synthesis, therapeutic use)

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