HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Sustained release of BCNU for the treatment of intraocular malignancies in animal models.

Abstract
Sustained release of 1,3-bis(2)chloroethyl)-1-nitrosourea (BCNU) via an episcleral implanted silicone device was used to treat Brown-Pearce epithelioma in the anterior chamber of rabbit eyes. One group of test eyes received BCNU dissolved in sesame oil; a second group received BCNU in pure ethanol. Control eyes received only the diluent, sesame oil or pure ethanol. The effectiveness of the various dosages and diluents was compared by clinical observation, by weight of the enucleated eyes, and by histopathologic examination. Sustained release of BCNU via an episcleral implanted silicone device delayed the growth of Brown-Pearce epithelioma in rabbit eyes of both test groups. The most effective action resulted from administration of BCNU in pure ethanol.
AuthorsH S Liu, M F Refojo, H D Perry, D M Albert
JournalInvestigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 18 Issue 10 Pg. 1061-7 (Oct 1979) ISSN: 0146-0404 [Print] United States
PMID478776 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Drug Implants
  • Pharmaceutical Vehicles
  • Silicone Elastomers
  • Ethanol
  • Sesame Oil
  • Carmustine
Topics
  • Animals
  • Anterior Chamber
  • Carcinoma, Brown-Pearce (drug therapy)
  • Carmustine (administration & dosage)
  • Drug Implants
  • Ethanol
  • Eye Neoplasms (drug therapy)
  • Female
  • Neoplasm Transplantation
  • Pharmaceutical Vehicles
  • Rabbits
  • Sesame Oil
  • Silicone Elastomers

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: