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The 'mauve factor' of schizophrenia and porphyria, 5-hydroxyhaemopyrrole lactam, has low pharmacological potency on guinea-pig ileum.

Abstract
5-Hydroxyhaemopyrrole lactam, the 'mauve factor' reported in the urine of schizophrenics and porphyrics was found to inhibit electrically-stimulated contractions of guinea-pig ileum only at high concentrations (ID50 = 8.5 mM). This low potency makes it unlikely that the compound can account for neurotoxic effects in human porphyria.
AuthorsA Gorchein, A T Rogers
JournalExperientia (Experientia) Vol. 35 Issue 8 Pg. 1078-9 (Aug 15 1979) ISSN: 0014-4754 [Print] Switzerland
PMID477885 (Publication Type: Journal Article)
Chemical References
  • Pyrroles
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Guinea Pigs
  • Humans
  • Ileum (drug effects, physiology)
  • Muscle Contraction (drug effects)
  • Porphyrias (urine)
  • Pyrroles (pharmacology, urine)
  • Rats
  • Schizophrenia (urine)

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