Abstract |
5-Hydroxyhaemopyrrole lactam, the ' mauve factor' reported in the urine of schizophrenics and porphyrics was found to inhibit electrically-stimulated contractions of guinea-pig ileum only at high concentrations (ID50 = 8.5 mM). This low potency makes it unlikely that the compound can account for neurotoxic effects in human porphyria.
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Authors | A Gorchein, A T Rogers |
Journal | Experientia
(Experientia)
Vol. 35
Issue 8
Pg. 1078-9
(Aug 15 1979)
ISSN: 0014-4754 [Print] Switzerland |
PMID | 477885
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Dose-Response Relationship, Drug
- Electric Stimulation
- Guinea Pigs
- Humans
- Ileum
(drug effects, physiology)
- Muscle Contraction
(drug effects)
- Porphyrias
(urine)
- Pyrroles
(pharmacology, urine)
- Rats
- Schizophrenia
(urine)
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