Abstract |
The abilities of 3-methylcholanthrene (3-MC) and 3,11-dimethylcholanthrene (3,11-DMC) to initiate skin tumors in Sencar mice were determined by using a 2-stage system of tumorigenesis. 3,11-DMC was found to have very weak skin tumor initiating activity when compared to the potent activity of 3-MC. The only difference between 3-MC and 3,11-DMC is the substitution of a methyl group in position 11 which is part of the 'K-region' or the 'peri' position. From these results, we suggest that an unhindered peri position adjacent to an angular benzene ring is necessary for carcinogenic activity of 3-MC.
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Authors | T J Slaga, G L Gleason, L Hardin |
Journal | Cancer letters
(Cancer Lett)
Vol. 7
Issue 2-3
Pg. 97-102
(Jul 1979)
ISSN: 0304-3835 [Print] Ireland |
PMID | 476615
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Methylcholanthrene
- 3,11-dimethylcholanthrene
- Tetradecanoylphorbol Acetate
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Topics |
- Animals
- Female
- Methylcholanthrene
(analogs & derivatives, toxicity)
- Mice
- Neoplasms, Experimental
(chemically induced)
- Papilloma
(chemically induced)
- Skin Neoplasms
(chemically induced)
- Structure-Activity Relationship
- Tetradecanoylphorbol Acetate
(administration & dosage)
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