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Comparison of the skin tumor initiating activity of 3-methylcholanthrene and 3,11-dimethylcholanthrene in mice.

Abstract
The abilities of 3-methylcholanthrene (3-MC) and 3,11-dimethylcholanthrene (3,11-DMC) to initiate skin tumors in Sencar mice were determined by using a 2-stage system of tumorigenesis. 3,11-DMC was found to have very weak skin tumor initiating activity when compared to the potent activity of 3-MC. The only difference between 3-MC and 3,11-DMC is the substitution of a methyl group in position 11 which is part of the 'K-region' or the 'peri' position. From these results, we suggest that an unhindered peri position adjacent to an angular benzene ring is necessary for carcinogenic activity of 3-MC.
AuthorsT J Slaga, G L Gleason, L Hardin
JournalCancer letters (Cancer Lett) Vol. 7 Issue 2-3 Pg. 97-102 (Jul 1979) ISSN: 0304-3835 [Print] Ireland
PMID476615 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Methylcholanthrene
  • 3,11-dimethylcholanthrene
  • Tetradecanoylphorbol Acetate
Topics
  • Animals
  • Female
  • Methylcholanthrene (analogs & derivatives, toxicity)
  • Mice
  • Neoplasms, Experimental (chemically induced)
  • Papilloma (chemically induced)
  • Skin Neoplasms (chemically induced)
  • Structure-Activity Relationship
  • Tetradecanoylphorbol Acetate (administration & dosage)

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