Mesotheliomas and proliferative lesions of the testicular mesothelium produced in Fischer, Sprague-Dawley and Buffalo rats by methyl(acetoxymethyl)nitrosamine (DMN-OAc).

Abstract

A single intraperitoneal dose of methyl(acetoxymethyl)nitrosamine (13 mg/kg body weight) given to 78 5-week-old male rats induced 25 mesotheliomas; two mesotheliomas were found in 67 control rats. All mesotheliomas arose from the peritesticular mesothelium and had a typical microscopic appearance of branching papillary fronds with a collagenous core covered by one or many layers of plump tumor cells. Cytoplasm of tumor cells contained material that reacted positively to a colloidal iron stain and was labile to hyaluronidase. In addition to frank mesotheliomas, 16 lesions, which we called atypical mesothelial proliferations, were found. These consisted of a single focus of plump mesothelial cells overlying an area of thick stroma. Often these foci included short, non-branched papillary projections above the surface of adjacent normal mesothelium. Twelve of the 16 lesions occurred in methyl(acetoxymethyl)nitrosamine-treated rats.

• Authors: J J Berman, J M Rice
• Journal: Veterinary pathology (Vet Pathol) Vol. 16 Issue 5 Pg. 574-82 (Sep 1979) ISSN: 0300-9858 [Print] United States
• PMID: 473488 (Publication Type: Journal Article)

Chemical References

• Nitrosamines
• Dimethylnitrosamine

Topics

• Animals
• Dimethylnitrosamine (analogs & derivatives)
• Disease Models, Animal
• Male
• Mesothelioma (chemically induced, pathology)
• Nitrosamines (analogs & derivatives)
• Rats
• Testicular Neoplasms (chemically induced, pathology)