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Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes.

Abstract
Numerous lines of mouse lymphoid tumors (13 of 22 tested) showed, with increased sensitivity, a property of normal mouse splenic lymphocytes, the potential for growth promotion in vitro by specific thiols added to standard culture media. For lymphoma L1210 (V), structure activity relationships were examined; 9 of 30 thiols promoted growth; the most active was alpha-thioglycerol, effective at 0.2 microM. Thiols became oxidized under conditions of tissue culture and had half-lives of less than 8 h. Disulfides of active thiols promoted growth of lymphoma cells. The mitogenic response of splenic lymphocytes to lectins was increased by thiols-disulfides which promoted the growth of lymphoma cells, but the response varied with the mitogen preparation used and under some conditions thiols-disulfides were inhibitory.
AuthorsJ D Broome, M W Jeng
JournalThe Journal of experimental medicine (J Exp Med) Vol. 138 Issue 3 Pg. 574-92 (Sep 01 1973) ISSN: 0022-1007 [Print] United States
PMID4727914 (Publication Type: Journal Article)
Chemical References
  • Disulfides
  • Mitogens
  • Sulfhydryl Compounds
  • Mercaptoethanol
  • Cysteine
  • Thymidine
Topics
  • Animals
  • Cell Line
  • Cells, Cultured
  • Cysteine (pharmacology)
  • Disulfides (pharmacology)
  • Half-Life
  • Leukemia L1210
  • Lymphocytes (drug effects)
  • Lymphoma
  • Mercaptoethanol (pharmacology)
  • Mice
  • Mitogens (pharmacology)
  • Mitosis (drug effects)
  • Spleen (cytology)
  • Structure-Activity Relationship
  • Sulfhydryl Compounds (pharmacology)
  • Thymidine (metabolism)

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