Perinatal exposure to cannabinoids alters male reproductive function in mice.

Abstract

Oral administration of delta 9-tetrahydrocannabinol or cannabinol to female mice late in pregnancy and during early lactation alters body weight regulation and pituitary-gonadal function and suppresses adult copulatory activity in their male offspring. These findings suggest that both psychoactive and nonpsychoactive constituents of marihuana can affect the development of male reproductive functions in mice.

• Authors: S Dalterio, A Bartke
• Journal: Science (New York, N.Y.) (Science) Vol. 205 Issue 4413 Pg. 1420-2 (Sep 28 1979) ISSN: 0036-8075 [Print] United States
• PMID: 472762 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cannabinoids
• Pituitary Hormones
• Testosterone
• Dronabinol
• Cannabinol

Topics

• Animals
• Animals, Newborn
• Body Weight (drug effects)
• Cannabinoids (pharmacology)
• Cannabinol (pharmacology)
• Copulation (drug effects)
• Dronabinol (pharmacology)
• Male
• Mice
• Organ Size (drug effects)
• Pituitary Hormones (blood)
• Sex Differentiation (drug effects)
• Sexual Behavior, Animal (drug effects)
• Sexual Maturation (drug effects)
• Testis (anatomy & histology)
• Testosterone (blood)