Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase.

Abstract	An L-glutaminase-L-asparaginase from Achromobacter has been rendered nonimmunogenic by the covalent attachment of polyethylene glycol (PEG) to nonessential amine groups of the enzyme. PEG-L-glutaminase-L-asparaginase exhibits a greatly enhanced half-life in the bloodstream compared to the unmodified enzyme in normal mice, and is effective in prolonging the survival of BDF1 mice inoculated ip with L5178Y cells. PEG-L-glutaminase-L-asparaginase appears rapidly in the blood following ip injection.
Authors	A Abuchowski, T van Es, N C Palczuk, J R McCoy, F F Davis
Journal	Cancer treatment reports (Cancer Treat Rep) Vol. 63 Issue 6 Pg. 1127-32 (Jun 1979) ISSN: 0361-5960 [Print] United States
PMID	466651 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Glutamine polyethylene glycol-glutaminase-asparaginase Polyethylene Glycols Asparagine Amidohydrolases Asparaginase Glutaminase
Topics	Amidohydrolases (administration & dosage, blood, immunology) Animals Antibody Formation Asparaginase Asparagine Drug Therapy, Combination Glutaminase Glutamine Metabolic Clearance Rate Mice Neoplasms, Experimental (drug therapy) Polyethylene Glycols

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