[Factor analysis of the effectiveness of combined therapy in experimental leukemia].

Abstract

The effectiveness of the combined therapy of leukemia P-388 with cyclophosphane and diazane was studied. The pattern of administering these substances was selected with due consideration of the cyclospecificity of their action. In a number of cases considerable synergism was observed, resulting in a cure of 100% of animals. Estimation of the effectiveness and the degree of synergism was made by the method of fractionation analysis, which allowed delineating some trends for providing the optimum combined therapy.

• Authors: N M Emanuél', N P Konovalova, L M Volkova, V V Rusanov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 25 Issue 6 Pg. 96-100 ( 1979) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Faktornyĭ analiz éffektivnosti kombinirovannoĭ terapii éksperimental'nykh leĭkozov.
• PMID: 462879 (Publication Type: English Abstract, Journal Article)

Chemical References

• Azo Compounds
• Succinates
• Cyclophosphamide

Topics

• Animals
• Azo Compounds (administration & dosage)
• Computers
• Cyclophosphamide (administration & dosage)
• Drug Evaluation, Preclinical
• Drug Synergism
• Drug Therapy, Combination
• Factor Analysis, Statistical
• Leukemia, Experimental (drug therapy)
• Mice
• Mice, Inbred Strains
• Succinates (administration & dosage)