[Dynamics of the connective tissue changes in rats in the process of tumor formation induced by ethacryl (AKR-15) plastic].

Abstract

Morphological studies of the rat connective tissue around the implanted plates, made from a plastic Ethacryl (AKP-15) being employed in orthopedic stomatology, have demonstrated a gradual reduction of the proliferative activity of the connective tissue capsule fibroblasts, followed 6 months later by the appearance of diffuse and then focal proliferates in the internal layer with subsequent development of tumors. A histological assay of the collagen-formation revealed no dystrophic changes in the connective tissue characteristic of other types of blastomogenesis. The pattern of diformazane depositing, when histochemically assaying oxido-reduction enzymes, may evidence the cell damage of the connective tissue capsules around the implant in the first months of the experiment.

• Authors: V V Rliseev
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 25 Issue 6 Pg. 65-9 ( 1979) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Dinamika izmeneniĭ soedinitel'noĭ tkani krys v protsesse formirovanie opukholeĭ, vyzvannykh plastmassoĭ étakril (AKR-15).
• PMID: 462876 (Publication Type: Journal Article)

Chemical References

• Acrylic Resins
• Carcinogens
• Plastics
• etacryl
• Oxidoreductases

Topics

• Acrylic Resins
• Administration, Topical
• Animals
• Carcinogens
• Cell Transformation, Neoplastic (drug effects)
• Connective Tissue (drug effects, enzymology)
• Enzyme Activation (drug effects)
• Neoplasms, Experimental (chemically induced)
• Oxidoreductases (metabolism)
• Plastics
• Rats
• Skin Neoplasms (chemically induced)
• Time Factors