Functional evaluation of prolactin secretion: a guide to therapy.

Abstract

Stimulation and inhibition tests are proposed for evaluating prolactin secretion. Thyrotropin-releasing hormone (TRH) stimulates the release of prolactin from the pituitary. Chlorpromazine acts presumably at the hypothalamic level to increase prolactin secretion. L-Dopa (D,L-alpha-hydrazino-alpha-methyl-beta-[3,4-di-hydroxyphenyl]) has the opposite effect; it inhibits prolactin secretion and may be effective in suppressing galactorrhea.

• Authors: H Friesen, H Guyda, P Hwang, J E Tyson, A Barbeau
• Journal: The Journal of clinical investigation (J Clin Invest) Vol. 51 Issue 3 Pg. 706-9 (Mar 1972) ISSN: 0021-9738 [Print] United States
• PMID: 4622109 (Publication Type: Journal Article)

Chemical References

• Thyrotropin-Releasing Hormone
• Dihydroxyphenylalanine
• Prolactin
• Thyrotropin
• Chlorpromazine

Topics

• Administration, Oral
• Adolescent
• Adult
• Child, Preschool
• Chlorpromazine (administration & dosage, pharmacology)
• Dihydroxyphenylalanine (administration & dosage, pharmacology, therapeutic use)
• Female
• Humans
• Injections, Intramuscular
• Injections, Intravenous
• Lactation Disorders (drug therapy)
• Male
• Pituitary Gland (drug effects, metabolism)
• Pregnancy
• Prolactin (antagonists & inhibitors, blood, metabolism)
• Radioimmunoassay
• Thyrotropin (blood)
• Thyrotropin-Releasing Hormone (administration & dosage, pharmacology)