Sotalol for the protection of turkeys from the development of -aminopropionitrile-induced aortic ruptures.

Abstract

1. The influence of feeding 2 levels of sotalol on the incidence of beta-aminopropionitrile (BAPN)-induced aortic ruptures of immature turkeys was determined.2. Four of 22 turkeys fed 0.12% sotalol and 0.07% BAPN died of aortic ruptures, but 6 of 21 turkeys fed only BAPN died of the syndrome.3. Blood pressure, heart rate, aortic tensile strength, and aortic structure as seen by light- and electron-microscope were similar in turkeys fed BAPN alone or both BAPN and 0.12% sotalol concurrently.4. In a second experiment, 13 of 24 turkeys fed 0.7% BAPN alone died of aortic ruptures, but only 2 of 24 turkeys fed BAPN and 0.2% sotalol concurrently died of the disease.5. Aortic tensile strength was lower, heart rate was faster, alterations of aortic elastic fibres as seen by light- and electron-microscope were more severe, and aortic salt soluble collagen with a higher amino acid content was increased in turkeys fed only BAPN, as compared to turkeys fed both BAPN and 0.2% sotalol.

• Authors: C F Simpson
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 45 Issue 3 Pg. 385-90 (Jul 1972) ISSN: 0007-1188 [Print] England
• PMID: 4561180 (Publication Type: Journal Article)

Chemical References

• Aminopropionitrile
• Sotalol

Topics

• Aminopropionitrile
• Animals
• Aorta (pathology)
• Aortic Rupture (chemically induced, pathology, prevention & control)
• Blood Pressure (drug effects)
• Drug Interactions
• Heart Rate (drug effects)
• Histological Techniques
• Microscopy, Electron
• Sotalol (therapeutic use)
• Syndrome
• Turkeys