Antitumor activity of some microbial and chemical transformation products of anguidine (4,15-diacetoxyscirpene-3-ol).

Abstract

The in vivo antitumor activities, as measured by inhibition of transplanted P-388 and L-1210 leukemia in mice, have been determined for a series of analogs of anguidine including triacetoxyscirpenol, the three diacetoxyscirpenols, the three monoacetoxyscirpenols, and scirpenetriol. An acetoxy function at position 15 appears to be required for good activity.

• Authors: C A Claridge, H Schmitz, W T Bradner
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 2 Issue 3 Pg. 181-2 ( 1979) ISSN: 0344-5704 [Print] Germany
• PMID: 455572 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Sesquiterpenes
• Trichothecenes

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• HeLa Cells (drug effects)
• Leukemia L1210 (drug therapy)
• Leukemia, Experimental (drug therapy)
• Mice
• Mice, Inbred DBA
• Mice, Inbred Strains
• Neoplasm Transplantation
• Sesquiterpenes (therapeutic use)
• Structure-Activity Relationship
• Trichothecenes (pharmacology, therapeutic use)