Comparison of aspirin and benorylate in the treatment of rheumatoid arthritis.

Abstract

In a double-blind between-patient study of aspirin and benorylate carried out in 72 outpatients with rheumatoid arthritis, benorylate 4 g twice daily was shown to be an effective analgesic and anti-inflammatory drug, its effects being indistinguishable from those of aspirin 1.2 g four times daily. Compared with the pretreatment values both drugs produced a statistically significant improvement (P < 0.01) in functional grade, overall pain, articular index, and grip strength at the end of the first and second weeks. The overall incidence of side effects was less with benorylate, though this difference was not significant at the 5% level.

• Authors: D L Beales, H C Burry, R Grahame
• Journal: British medical journal (Br Med J) Vol. 2 Issue 5812 Pg. 483-5 (May 27 1972) ISSN: 0007-1447 [Print] England
• PMID: 4555545 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Analgesics
• Aniline Compounds
• Anti-Inflammatory Agents
• Phenols
• Salicylates
• Aspirin

Topics

• Adolescent
• Adult
• Aged
• Analgesics (administration & dosage, adverse effects)
• Aniline Compounds (administration & dosage, adverse effects)
• Anti-Inflammatory Agents (administration & dosage, adverse effects)
• Arthritis, Rheumatoid (drug therapy)
• Aspirin (administration & dosage, adverse effects)
• Clinical Trials as Topic
• Female
• Gastrointestinal Hemorrhage (prevention & control)
• Humans
• Male
• Middle Aged
• Movement
• Pain (drug therapy)
• Phenols (administration & dosage, adverse effects)
• Physical Examination
• Salicylates (administration & dosage, adverse effects)
• Tinnitus (chemically induced)