Electron microscopic studies of the heart and light microscopic studies of the skin after treatment of golden hamsters with adriamycin, detorubicin, AD-32, and aclacinomycin.

Abstract

Golden hamsters received Adriamycin (ADR), detorubicin (DTR), AD-32, or aclacinomycin (ACM) three times weekly at doses extrapolated from optimal doses in L1210 leukemia. Minimal early lesions of the myocardium were detected by electron microscopy in ACM-treated animals. These lesions were aggravated after several weeks of treatment but remained reversible. Lesions in AD-32-treated hamsters were slightly more marked than those seen in ACM-treated animals but were much less severe than those observed in ADR- or DTR-treated animals. Similarly, light microscopy revealed pathologic changes in the skin following ADR or DTR administration. These changes were not seen in animals receiving AD-32 or ACM.

• Authors: D Dantchev, V Slioussartchouk, M Paintrand, M Hayat, C Bourut, G Mathé
• Journal: Cancer treatment reports (Cancer Treat Rep) Vol. 63 Issue 5 Pg. 875-88 (May 1979) ISSN: 0361-5960 [Print] United States
• PMID: 455329 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibiotics, Antineoplastic
• Naphthacenes
• aclacinomycins
• valrubicin
• Aclarubicin
• Doxorubicin
• Daunorubicin

Topics

• Aclarubicin (analogs & derivatives)
• Animals
• Antibiotics, Antineoplastic (adverse effects)
• Cricetinae
• Daunorubicin (administration & dosage, analogs & derivatives)
• Doxorubicin (administration & dosage, adverse effects, analogs & derivatives)
• Drug Administration Schedule
• Heart (drug effects)
• Leukemia L1210 (drug therapy)
• Mesocricetus
• Microscopy, Electron
• Myocardium (ultrastructure)
• Naphthacenes (administration & dosage, adverse effects)
• Skin (drug effects, pathology)