Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect.

Abstract

The relationship between cell-mediated immunity to the carrier and the carrier-hapten helper effect was studied in the rat by using three forms of the carrier which differed in their capacity to induce carrier-specific delayed-type hypersensitivity. The three carriers were polymerized flagellin (POL), flagellin (FIN), and acetoacetylated flagellin (AFIN), which induced FIN-specific delayed-type hypersensitivity in the order AFIN > FIN > POL. Helper cells for the anti-DNP antibody responses to a range of DNP-FIN conjugates appeared to be almost inversely related to cell-mediated immunity to the carrier, being in the order POL > FIN =/> AFIN. These differences occurred whether the carriers were injected in saline or FCA, but were less pronounced with the heavily DNP-conjugated flagellins.

• Authors: F Y Liew, C R Parish
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 139 Issue 3 Pg. 779-84 (Mar 01 1974) ISSN: 0022-1007 [Print] United States
• PMID: 4544249 (Publication Type: Journal Article)

Chemical References

• Antigens, Bacterial
• Carrier Proteins
• Dinitrophenols
• Haptens
• Serum Albumin, Bovine

Topics

• Animals
• Antibody Formation
• Antibody-Producing Cells
• Antigens, Bacterial
• Carrier Proteins
• Dinitrophenols (pharmacology)
• Female
• Flagella (immunology)
• Haptens
• Hemagglutination Tests
• Hypersensitivity, Delayed
• Immunity, Cellular
• Immunization
• Rats
• Salmonella (immunology)
• Serum Albumin, Bovine
• Sheep (immunology)
• T-Lymphocytes (immunology)