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Critical test evaluation of butamisole against gastrointestinal parasites of horses and ponies.

Abstract
A critical test was performed to evaluate the anthelmintic properties of an injectable butamisole formulation and to compare the efficiency with that of a commercially available piperazine-thiabendazole anthelmintic. The test was done in 10 horses and 15 ponies with naturally acquired parasitic infections. Butamisole was administered at the dose level of 2.5 or 3.75 mg/kg of body weight by either subcutaneous or deep intramuscular injection. Given at the dose level of 2.5 mg/kg, butamisole was highly effective (99%) against Strongylus vulgaris and moderately effective (49%) against Parascaris equorum. At the 3.75 mg/kg dose rate, butamisole was highly effective against both S vulgaris (97%) and P equorum (94%). Butamisole had limited efficacy against other parasite species. Signs of toxicosis, long-term swelling of the injection sites, or tissue damage were not seen after injection.
AuthorsR B Grieve, B G Moore, R E Bradley Sr
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 40 Issue 1 Pg. 139-41 (Jan 1979) ISSN: 0002-9645 [Print] United States
PMID453676 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anthelmintics
  • Imidazoles
  • Piperazines
  • Thiazoles
  • Thiabendazole
  • butamisole
Topics
  • Animals
  • Anthelmintics (therapeutic use)
  • Horse Diseases (drug therapy)
  • Horses
  • Imidazoles (administration & dosage, therapeutic use)
  • Injections, Intramuscular
  • Injections, Subcutaneous
  • Nematode Infections (drug therapy, veterinary)
  • Piperazines (therapeutic use)
  • Strongyle Infections, Equine (drug therapy)
  • Thiabendazole (therapeutic use)
  • Thiazoles (administration & dosage, therapeutic use)

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