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Effect of stimulation of the host defense system by coenzyme Q 10 on dibenzpyrene-induced tumors and infection with Friend leukemia virus in mice.

Abstract
Members of the coenzyme Q group increase the phagocytic activity in rats, as measured by the carbon clearance technique, and increase the hemolytic antibody formation in mice. In addition, prior treatment with low doses of chloroquine hydrochloride combined with coenzyme Q(10) results in increased numbers of survivors, prolonged survival time, and reduced parasitemia in blood-transferred Plasmodium berghei infection in miceIn an extension of these studies, using emulsions of coenzyme Q(10), I demonstrated the following effects on two tumor systems in mice: (i) Treatment with coenzyme Q(10) decreased splenomegaly and hepatomegaly and increased the number of surviving mice infected with Friend leukemia virus. (ii) Treatment with coenzyme Q(10) reduced the percentage of mice with tumors, increased the number of survivors, and reduced the tumor size in mice with tumors induced by 3,4,9,10-dibenzpyrene. The effect on both tumor systems was dose-dependent. These studies support the hypothesis that the host defense system plays a definitive role in the defense of the host against invasion by various agents, including neoplasia.
AuthorsE G Bliznakov
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 70 Issue 2 Pg. 390-4 (Feb 1973) ISSN: 0027-8424 [Print] United States
PMID4510283 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Benzopyrenes
  • Ubiquinone
Topics
  • Animals
  • Antibody Formation (drug effects)
  • Antineoplastic Agents (therapeutic use)
  • Benzopyrenes
  • Body Weight
  • Friend murine leukemia virus
  • Hepatomegaly (drug therapy)
  • Leukemia, Experimental (drug therapy, etiology, immunology, mortality, pathology)
  • Liver (pathology)
  • Male
  • Mice
  • Neoplasms, Experimental (chemically induced, drug therapy, immunology, mortality, pathology)
  • Organ Size
  • Spleen (pathology)
  • Splenomegaly (drug therapy)
  • Ubiquinone (pharmacology, therapeutic use)

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