Abstract |
Administration of oil-attached Nocardia rubra cell-wall skeleton (N. rubra-CWS) was evaluated for the effect of the induction of lung cancers in ACI/N rats. Lung cancers were induced by 15 weekly intratracheal instillations of 3 mg benzo[a]-pyrene with 3 mg ferric oxide. After the 10th instillation of the carcinogen, rats received seven subcutaneous injections of 100 microgram of N. rubra-CWS at 2-week intervals. In the observation period of 56 weeks, the cumulative incidence of lung cancer was 71.4% in the control group and 48.0% in the N. rubra-CWS treated group. The latent period of tumor induction was prolonged in the group treated with N. rubra-CWS.
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Authors | M Namba, T Yoshimoto, T Ogura, F Hirao, I Azuma, Y Yamamura |
Journal | Gan
(Gan)
Vol. 70
Issue 1
Pg. 55-62
(Feb 1979)
ISSN: 0016-450X [Print] Japan |
PMID | 446976
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Benzopyrenes
- Carcinoma, Squamous Cell
(chemically induced, immunology, prevention & control)
- Cell Wall
(immunology)
- Fibrosarcoma
(chemically induced, immunology)
- Lung Neoplasms
(chemically induced, immunology, prevention & control)
- Male
- Neoplasms, Experimental
(chemically induced, prevention & control)
- Nocardia
(immunology)
- Rats
- Rats, Inbred ACI
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