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Effect of Nocardia rubra cell-wall skeleton on the induction of lung cancer in ACI/N rats.

Abstract
Administration of oil-attached Nocardia rubra cell-wall skeleton (N. rubra-CWS) was evaluated for the effect of the induction of lung cancers in ACI/N rats. Lung cancers were induced by 15 weekly intratracheal instillations of 3 mg benzo[a]-pyrene with 3 mg ferric oxide. After the 10th instillation of the carcinogen, rats received seven subcutaneous injections of 100 microgram of N. rubra-CWS at 2-week intervals. In the observation period of 56 weeks, the cumulative incidence of lung cancer was 71.4% in the control group and 48.0% in the N. rubra-CWS treated group. The latent period of tumor induction was prolonged in the group treated with N. rubra-CWS.
AuthorsM Namba, T Yoshimoto, T Ogura, F Hirao, I Azuma, Y Yamamura
JournalGan (Gan) Vol. 70 Issue 1 Pg. 55-62 (Feb 1979) ISSN: 0016-450X [Print] Japan
PMID446976 (Publication Type: Journal Article)
Chemical References
  • Benzopyrenes
Topics
  • Animals
  • Benzopyrenes
  • Carcinoma, Squamous Cell (chemically induced, immunology, prevention & control)
  • Cell Wall (immunology)
  • Fibrosarcoma (chemically induced, immunology)
  • Lung Neoplasms (chemically induced, immunology, prevention & control)
  • Male
  • Neoplasms, Experimental (chemically induced, prevention & control)
  • Nocardia (immunology)
  • Rats
  • Rats, Inbred ACI

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