Hypotensive and vasodilator actions of SK&F 24260, a new dihydropyridine derivative.

Abstract

1 The blood pressure of conscious normotensive, Goldblatt-hypertensive and genetic-hypertensive rats and normotensive dogs was lowered by SK&F 24260 (1,4-dihydro-2,6-dimethyl-4-(2-trifluormethylphenyl)-3,5-pyridinedicarboxylic acid diethyl ester).2 Tachycardia always accompanied the hypotension. In rats propranolol abolished the tachycardia but in dogs there was only a small reduction in the heart rate response.3 In conscious dogs there was an increase in left ventricular output and a marked fall in total peripheral resistance.4 SK&F 24260 dilated resistance vessels in rat hindquarters. Dilatation was caused by doses of SK&F 24260 some 50 times smaller than those of hydrallazine.5 In preparations of cat skeletal muscle and intestinal vascular beds SK&F 24260 selectively dilated resistance vessels in preference to capacitance vessels and resembled hydrallazine rather than papaverine which has no such selectivity.6 Pre-capillary sphincter vessels were also dilated by SK&F 24260. Changes in fluid equilibrium caused by SK&F 24260 were consistent with selective dilatation of resistance vessels.

• Authors: R Fielden, D A Owen, E M Taylor
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 52 Issue 3 Pg. 323-32 (Nov 1974) ISSN: 0007-1188 [Print] England
• PMID: 4458842 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Dicarboxylic Acids
• Dihydropyridines
• Hydrocarbons, Fluorinated
• Pyridines
• Vasodilator Agents
• 1,4-dihydro- 2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-3,5- pyridinedicarboxylic acid diethyl ester

Topics

• Animals
• Antihypertensive Agents (pharmacology)
• Blood Pressure (drug effects)
• Cats
• Dicarboxylic Acids (pharmacology)
• Dihydropyridines
• Dogs
• Female
• Heart Rate (drug effects)
• Hindlimb (blood supply)
• Hydrocarbons, Fluorinated (pharmacology)
• Male
• Mesentery (blood supply)
• Muscles (blood supply)
• Pyridines (pharmacology)
• Rats
• Rats, Inbred Strains
• Regional Blood Flow (drug effects)
• Vasodilator Agents (pharmacology)