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Characterization of rat hepatoma glucosamine 6-phosphate synthase and its relation to liver and fetal forms.

Abstract
Glucosamine 6-phosphate synthase (EC 5.3.1.19) purified from various rat tissues by a procedure involving chromatography on diethylaminoethyl Sephadex and hydroxylapatite were characterized by means of isoelectric focusing. The non-hepatic isozyme, previously reported to be present in Yoshida sarcoma, has a pI of 4.1 and is distinguished from the hepatic isozyme, with a pI of 5.0. The pI 4.1 form is the major one in all of the fast-growing, transplantable hepatomas studied. Although not detectable in 19-day fetal liver or normal adult liver, the pI 4.1 form has been observed in the whole 12-day fetus and adult brain as almost the sole form of glucosamine 6-phosphate synthase.
AuthorsT Miyagi, S Tsuiki
JournalCancer research (Cancer Res) Vol. 39 Issue 7 Pt 1 Pg. 2779-82 (Jul 1979) ISSN: 0008-5472 [Print] United States
PMID445481 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
  • Carbohydrate Epimerases
Topics
  • Animals
  • Brain (enzymology)
  • Carbohydrate Epimerases (metabolism)
  • Fetus
  • Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) (metabolism)
  • Isoelectric Focusing
  • Liver (enzymology)
  • Liver Neoplasms, Experimental (enzymology)
  • Male
  • Rats

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