HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Role of adrenals and estrogen in regression of mammary tumors during postpartum lactation in the rat.

Abstract
The effects of bilateral adrenalectomy or estradiol benzoate treatment were observed on growth of 7,12-dimethylbenz(a)-anthracene-induced mammary tumors during postpartum lactation. In the control and estradiol benzoate-treated postpartum lactating rats, the mammary tumors decreased approximately 40% in size by Day 5 postpartum and continued to regress to 50% of their average original diameter by Day 25 postpartum. Adrenalectomy on Day 3 postpartum prevented mammary tumor regression and resulted in renewed mammary tumor growth. By Day 10 postpartum, average mammary tumor size in the adrenalectomized rats reached prepartum diameter and continued to increase in size until Day 25. Although serum prolactin concentrations were significantly higher in the lactating rats with mammary tumors than in the nonlactating rats with mammary tumors, there were no significant differences in serum corticosterone values. Adrenalectomy resulted in a significant increase in serum prolactin levels and in a marked fall in serum corticosterone levels. It is concluded that in rats adrenocortical activity is primarily responsible for reduced mammary tumor growth during postpartum lactation.
AuthorsC F Aylsworth, C A Hodson, G Berg, G Kledzik, J Meites
JournalCancer research (Cancer Res) Vol. 39 Issue 7 Pt 1 Pg. 2436-9 (Jul 1979) ISSN: 0008-5472 [Print] UNITED STATES
PMID445443 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Estrogens
  • Estradiol
  • Prolactin
  • Corticosterone
Topics
  • Adrenal Glands (physiology)
  • Adrenalectomy
  • Animals
  • Corticosterone (blood)
  • Estradiol (pharmacology)
  • Estrogens (physiology)
  • Female
  • Lactation
  • Mammary Neoplasms, Experimental (physiopathology)
  • Neoplasm Regression, Spontaneous
  • Pregnancy
  • Prolactin (blood)
  • Rats
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: