Some inhibitory effects of (--)-emetine on growth of Ehrlich ascites carcinoma.

(-)-Emetine has little or no effect on O(2) consumption of Ehrlich ascites-cell suspensions or on the viability of transplanted Ehrlich ascites-tumour cells exposed to, or incubated with, the drug in vitro before inoculation into new-host mice. (-)-Emetine administered as a single injection to mice bearing Ehrlich ascites-tumour cells slows the growth rate of the tumour. The subcutaneous or intraperitoneal injection of the drug depresses protein and DNA synthesis of the tumour cells in vivo in a reversible manner. Mice bearing ascitic sarcoma 180 or Ehrlich ascites-tumour cells when given a course of treatment with (-)-emetine or (-)-O-methyltubulosine have a substantially lower tumour load than untreated controls and correspondingly longer survival times.
AuthorsR K Johnson, W R Jondorf
JournalThe Biochemical journal (Biochem J) Vol. 140 Issue 1 Pg. 87-94 (Apr 1974) ISSN: 0264-6021 [Print] ENGLAND
PMID4451553 (Publication Type: Journal Article)
Chemical References
  • DNA, Neoplasm
  • Neoplasm Proteins
  • Leucine
  • Thymidine
  • Emetine
  • Animals
  • Carcinoma, Ehrlich Tumor (metabolism)
  • DNA, Neoplasm (biosynthesis)
  • Emetine (analogs & derivatives, pharmacology)
  • Leucine (metabolism)
  • Mice
  • Mice, Inbred ICR
  • Neoplasm Proteins (biosynthesis)
  • Neoplasm Transplantation
  • Oxygen Consumption (drug effects)
  • Protein Biosynthesis (drug effects)
  • Sarcoma 180 (metabolism)
  • Thymidine (metabolism)
  • Time Factors

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