Some inhibitory effects of (--)-emetine on growth of Ehrlich ascites carcinoma.

Abstract

(-)-Emetine has little or no effect on O(2) consumption of Ehrlich ascites-cell suspensions or on the viability of transplanted Ehrlich ascites-tumour cells exposed to, or incubated with, the drug in vitro before inoculation into new-host mice. (-)-Emetine administered as a single injection to mice bearing Ehrlich ascites-tumour cells slows the growth rate of the tumour. The subcutaneous or intraperitoneal injection of the drug depresses protein and DNA synthesis of the tumour cells in vivo in a reversible manner. Mice bearing ascitic sarcoma 180 or Ehrlich ascites-tumour cells when given a course of treatment with (-)-emetine or (-)-O-methyltubulosine have a substantially lower tumour load than untreated controls and correspondingly longer survival times.

• Authors: R K Johnson, W R Jondorf
• Journal: The Biochemical journal (Biochem J) Vol. 140 Issue 1 Pg. 87-94 (Apr 1974) ISSN: 0264-6021 [Print] England
• PMID: 4451553 (Publication Type: Journal Article)

Chemical References

• DNA, Neoplasm
• Neoplasm Proteins
• O-methyltubulosine
• Leucine
• Thymidine
• Emetine

Topics

• Animals
• Carcinoma, Ehrlich Tumor (metabolism)
• DNA, Neoplasm (biosynthesis)
• Emetine (analogs & derivatives, pharmacology)
• Leucine (metabolism)
• Mice
• Mice, Inbred ICR
• Neoplasm Proteins (biosynthesis)
• Neoplasm Transplantation
• Oxygen Consumption (drug effects)
• Protein Biosynthesis (drug effects)
• Sarcoma 180 (metabolism)
• Thymidine (metabolism)
• Time Factors