Mucocutaneous eruptions due to antiepileptic drug therapy in children.

Abstract

Three children with bullous erythema multiforme and 1 with toxic epidermal necrolysis associated with antiepileptic drug therapy are described. One patient is unique because of seven mucocutaneous eruptions caused by three classes of antiepileptic drugs. Lymphocyte stimulation by antiepileptic drugs could not be demonstrated in the 2 patients in whom appropriate studies were performed, and no precipitating antibodies to antiepileptic drugs were found. Observation of four diagnostic and therapeutic principles, which are illustrated by the course of our patients, may reduce the incidence of life-threatening mucocutaneous eruptions and simplify the long-term management of individuals in whom such reactions occur.

• Authors: M A Pollack, P G Burk, G Nathanson
• Journal: Annals of neurology (Ann Neurol) Vol. 5 Issue 3 Pg. 262-7 (Mar 1979) ISSN: 0364-5134 [Print] United States
• PMID: 443758 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Primidone
• Carbamazepine
• Phenytoin
• Mephenytoin
• Phenobarbital

Topics

• Anticonvulsants (adverse effects)
• Carbamazepine (adverse effects)
• Child
• Child, Preschool
• Erythema Multiforme (chemically induced, immunology)
• Female
• Humans
• Male
• Mephenytoin (adverse effects)
• Phenobarbital (adverse effects)
• Phenytoin (adverse effects)
• Primidone (adverse effects)
• Stevens-Johnson Syndrome (etiology, immunology)