Comparison of therapeutic routes in experimental Pseudomonas keratitis.

We determined the efficacy of tobramycin administered by topical, intramuscular, and subconjunctival routes in guinea pigs and rabbits with experimental Pseudomonas keratitis. The topical route of administration was consistently more effective than either subconjunctival or intramuscular routes. Subconjunctival injection of antibiotic did not enhance the effectiveness of topical therapy in either guinea pigs or rabbits. Intramuscular tobramycin was more effective than saline in guinea pigs with keratitis but not in rabbits with keratitis.
AuthorsS D Davis, L D Sarff, R A Hyndiuk
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 87 Issue 5 Pg. 710-6 (May 1979) ISSN: 0002-9394 [Print] UNITED STATES
PMID443343 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Anti-Bacterial Agents
  • Tobramycin
  • Administration, Topical
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Disease Models, Animal
  • Guinea Pigs
  • Humans
  • Injections
  • Injections, Intramuscular
  • Keratitis (drug therapy)
  • Kinetics
  • Pseudomonas Infections (drug therapy)
  • Rabbits
  • Tobramycin (pharmacology, therapeutic use)

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