Estradiol 17 beta-dehydrogenase and estradiol binding in human mammary tumors.

Abstract

The metabolism of estradiol was studied in 31 human breast carcinoma in vitro. All 16 estrogen-receptor-poor tumors transformed estradiol to estrone with percent conversions ranging from 11.4 to 95 except for one poorly differentiated tumor where 0.5% conversion to estrone was observed. On the contrary, only 3 out of 15 estrogen-receptor-rich tumors showed higher than 10% conversion of estradiol to estrone (p = 0.001). There is indication that the enzymatic activity in receptor-poor tumors steadily decreases in premenopausal patients as they approach menopausal age, whereas, the activity steadily increases in post-menopausal patients as the duration of menopause lengthens.

• Authors: Y J Abul-Hajj, R Iverson, D T Kiang
• Journal: Steroids (Steroids) Vol. 33 Issue 4 Pg. 477-84 (Apr 1979) ISSN: 0039-128X [Print] United States
• PMID: 442134 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, Estrogen
• Estradiol
• 17-Hydroxysteroid Dehydrogenases
• Estradiol Dehydrogenases

Topics

• 17-Hydroxysteroid Dehydrogenases (metabolism)
• Adult
• Age Factors
• Aged
• Breast Neoplasms (metabolism)
• Cytosol (metabolism)
• Estradiol (metabolism)
• Estradiol Dehydrogenases (metabolism)
• Female
• Humans
• Menopause
• Middle Aged
• Receptors, Estrogen (metabolism)