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Mixed-function oxidation in tumors.

Abstract
Liver microsomes of the rat contain a group of hydroxylating enzymes which are coupled to a greater or lesser degree to the electron flow system. In our studies, enzymes believed to be directly associated with the electron flow chain of NADPH, ferricyanide reduction, cytochrome c, cytochrome P-450 and substrate hydroxylation have been observed in livers obtained from normal, tumor-bearing and whole body irradiated rats as well as in Morris hepatoma 7777 and dimethyl-amino-biphenyl induced breast tumors.A significant difference appeared to exist in the activity of NADPH oxidase, NADP-ferricyanide reductase and benzopyrene hydroxylase when normal liver was compared with the liver obtained from a breast-tumor-bearing animal. Both cytochrome P-450 and cytochrome b(5) were decreased in the tumor-bearing animal.Tissue distribution of benzopyrene hydroxylase in normal, lactating and tumor-bearing Wistar rats has been studied.With the exception of NADPH oxidase, the activities of NADP-cytochrome c reductase, NADPH-ferricyanide reductase, benzopyrene hydroxylase and P-450 were markedly different in liver from Morris hepatoma 7777-bearing Buffalo rat when this was compared with homologous tissue obtained from normal Buffalo rat.Whole-body irradiated animals showed increased P-450 and NADPH oxidase activity in liver as a function of irradiation and there further appeared to be a correlation with decreased ferricyanide reductase activity.
AuthorsH D Brown, S K Chattopadhyay, S N Pennington, J S Spratt, H P Morris
JournalBritish journal of cancer (Br J Cancer) Vol. 25 Issue 1 Pg. 135-41 (Mar 1971) ISSN: 0007-0920 [Print] England
PMID4397226 (Publication Type: Journal Article)
Chemical References
  • Benzopyrenes
  • Biphenyl Compounds
  • Cytochromes
  • Ferricyanides
  • NADP
  • Mixed Function Oxygenases
  • Oxidoreductases
Topics
  • Animals
  • Benzopyrenes
  • Biphenyl Compounds
  • Carcinoma, Hepatocellular (enzymology)
  • Colon (enzymology)
  • Cytochromes (metabolism)
  • Electron Transport
  • Female
  • Ferricyanides (metabolism)
  • Kidney (enzymology)
  • Lactation
  • Liver Neoplasms (enzymology)
  • Lung (enzymology)
  • Male
  • Mammary Neoplasms, Experimental (chemically induced, enzymology)
  • Microsomes, Liver (enzymology, radiation effects)
  • Mixed Function Oxygenases (metabolism)
  • NADP (metabolism)
  • Neoplasms, Experimental
  • Oxidoreductases (metabolism)
  • Pregnancy
  • Radiation Effects
  • Rats

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