[Clinical evaluation of CS-1170 in pediatric field (author's transl)].

Abstract

CS-1170 was used for treatment of 26 children who were diagnosed as bacterial infections, and a response rate of 88% was obtained as the drug was effective in 15 of 17 determinable cases. In our evaluation, daily dosage of 75 approximately 270 mg/kg (100 approximately 200 mg/kg in the majority of the cases) was divided into 4 doses, and administered intravenously by one-shot injection over a 10-minute period. The period of drug administration ranged from 1.5 to 25.5 days, but in most cases it was 3 to 6 days. Elevation of GOT and GPT as a side effect of the drug was seen in one case (3.8%), which was reverted to normal level upon cessation of the drug administration.

• Authors: M Sawai, R Fujii
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 32 Issue 2 Pg. 247-52 (Feb 1979) ISSN: 0368-2781 [Print] Japan
• PMID: 439397 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephalosporins
• Cephamycins

Topics

• Acute Disease
• Age Factors
• Bacterial Infections (drug therapy)
• Cephalosporins (therapeutic use)
• Cephamycins (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Drug Evaluation
• Female
• Humans
• Infant
• Male