Abstract |
The authors have carried out the pharmacokinetics and clinical studies of CS-1170. The results were as follows; CS-1170 was given by drip infusion for 1 hour dose of 20 mg per kg body weight to 3 children. The maximum blood level was reached at one hour after drip infusion. This blood levels were 38 micrograms/ml, 68 micrograms/ml and 86 micrograms/ml, respectively, (mean 64 micrograms/ml), and level at 2 hours, 11.5 micrograms/ml, 9.4 micrograms/ml, 16 micrograms/ml respectively, (mean 12.3 micrograms/ml), the blood level at 6 hours was not determined. The urinary excretion rates were 94.8 approximately 96.8% up to 6 hours after drip infusion dose of 20 mg per kg body weight. CS-1170 was effective in 7 of 8 cases with pediatric bacterial infections. An ineffective case was a pneumonia due to Serratia marcescens. No side effect was observed except for 2 cases with diarrhea and one case with elevation of GOT and GPT.
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Authors | T Nishimura, Y Kotani, T Takashima, K Hiromatsu |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 32
Issue 2
Pg. 221-6
(Feb 1979)
ISSN: 0368-2781 [Print] Japan |
PMID | 439393
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Cephalosporins
- Cephamycins
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Topics |
- Adolescent
- Age Factors
- Bacterial Infections
(drug therapy)
- Cephalosporins
(metabolism)
- Cephamycins
(adverse effects, metabolism, therapeutic use)
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Kinetics
- Male
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