Interstitial cell carcinomas of the testis in Balb/C male mice ingesting methoxychlor.

Abstract

Balb/c and C3H strains male and female mice ingested 750 ppm methoxychlor or 100 ppm DDT in the diet for 2 years. Balb/c strain male mice ingesting methoxychlor developed a highly significant incidence of interstitial cell carcinomas of the testis. Balb/c strain male mice ingesting DDT and C3H strain male mice receiving methoxychlor or DDT did not have testicular tumors. The carcinomas of the testis varied from well-differentiated to poorly differentiated and undifferentiated and were capable of metastasis. Carcinomas of the testis have been described in Balb/c strain male mice, but not C3H, given estrogens. The carcinogenicity for testis of Balb/c strain male mice is most likely related to the estrogenic activity of methoxychlor.

• Authors: M D Reuber
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 93 Issue 2 Pg. 173-9 (Feb 19 1979) ISSN: 0171-5216 [Print] Germany
• PMID: 438281 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Estrogens
• DDT
• Methoxychlor

Topics

• Animals
• DDT (toxicity)
• Estrogens
• Male
• Methoxychlor (toxicity)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C3H
• Neoplasms, Experimental (chemically induced)
• Organ Specificity
• Species Specificity
• Testicular Neoplasms (chemically induced)