Abstract |
After 4 years of a long-term contraceptive steroid safety study, the incidence and the histologic types of mammary dysplasia produced are shown to be similar in beagles treated with medroxyprogesterone acetate ( medroxyprogesterone) or progesterone. Serum insulin, thyroid-stimulating hormone (TSH), triiodothyronine, growth hormone, prolactin, 17 beta-estradiol, progesterone, and cortisol were determined by radioimmunoassay on samples collected after 45 months of treatment. Serum growth hormone and insulin concentrations were elevated in a dose-related manner in both treatment groups. Levels of triiodothyronine, cortisol, and 17 beta-estradiol ( medroxyprogesterone only) were lowered. TSH and prolactin concentrations were not changed. Pituitary- gonadal hormone interaction in the pathogenesis of mammary neoplasia of the dog is discussed. Prolonged treatment of beagles with doses of progesterone or medroxyprogesterone 1 to 25 times the human contraceptive dose or luteal phase (dog) levels, respectively, results in a dose-related incidence of mammary nodules.
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Authors | D W Frank, K T Kirton, T E Murchison, W J Quinlan, M E Coleman, T J Gilbertson, E S Feenstra, F A Kimball |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 31
Issue 3
Pg. 340-6
(Mar 1979)
ISSN: 0015-0282 [Print] United States |
PMID | 437169
(Publication Type: Journal Article)
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Chemical References |
- Hormones
- Insulin
- Triiodothyronine
- Progesterone
- Estradiol
- Prolactin
- Thyrotropin
- Growth Hormone
- Medroxyprogesterone
- Hydrocortisone
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Topics |
- Adenoma
(chemically induced)
- Animals
- Dogs
- Dose-Response Relationship, Drug
- Estradiol
(blood)
- Female
- Growth Hormone
(blood)
- Hormones
(blood)
- Hydrocortisone
(blood)
- Hyperplasia
(chemically induced)
- Insulin
(blood)
- Mammary Glands, Animal
(drug effects, pathology)
- Medroxyprogesterone
(pharmacology)
- Neoplasms
(chemically induced)
- Progesterone
(blood, pharmacology)
- Prolactin
(blood)
- Thyrotropin
(blood)
- Time Factors
- Triiodothyronine
(blood)
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