[Effect of several diuretics on ischemic damage to the kidneys].

Abstract

Furosemide, etacrynic acid and mannitol administered to the survival of rats. However, these drugs prove ineffective in the event they are indicated after the action of the ischemic factor is discontinued. Etacrynic acid and novurit inhibit the functional activity of isolated mitochondria incubated under hypoxia and at a temperature of 37 degrees C.

• Authors: A V Dubishchev, N V Obraztsov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1979 Mar-Apr Vol. 42 Issue 2 Pg. 155-7 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie nekotorykh diuretikov na ishemicheskoe povrezhdenie pochek.
• PMID: 437083 (Publication Type: English Abstract, Journal Article)

Chemical References

• Diuretics
• Organomercury Compounds
• Mannitol
• Unithiol
• Furosemide
• Ethacrynic Acid

Topics

• Animals
• Diuretics (pharmacology, therapeutic use)
• Ethacrynic Acid (therapeutic use)
• Furosemide (therapeutic use)
• In Vitro Techniques
• Ischemia (drug therapy, prevention & control)
• Kidney (blood supply)
• Mannitol (therapeutic use)
• Mitochondria (drug effects)
• Organomercury Compounds (administration & dosage, therapeutic use)
• Oxygen Consumption (drug effects)
• Rats
• Unithiol (therapeutic use)