Brominated benzene induction of hepatic porphyria.

Abstract

Unlike the highly porphyrinogenic fungicide hexachlorobenzene, hexabromobenzene was a poor inducer of porphyria. Similarly, 1,2-dibromobenzene and 1,2,4-tribromobenzene, while causing small increases in hepatic porphyrins, did not increase ALA synthetase or the urinary excretion of porphobilinogen (PBG), aminolevulinic acid (ALA) or porphyrins.

• Authors: G P Carlson
• Journal: Experientia (Experientia) Vol. 35 Issue 4 Pg. 513-4 (Apr 15 1979) ISSN: 0014-4754 [Print] Switzerland
• PMID: 437040 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Bromobenzenes
• Porphyrins
• Aminolevulinic Acid

Topics

• Aminolevulinic Acid (metabolism)
• Animals
• Bromobenzenes
• Female
• Liver (metabolism)
• Porphyrias (chemically induced)
• Porphyrins (metabolism, urine)
• Rats
• Structure-Activity Relationship