Neuroblastoma: drug-induced differentiation increases proportion of cytoplasmic RNA that contains polyadenylic acid.

Abstract

The production of cytoplasmic RNA that contains polyadenylic acid is increased, relative to total cytoplasmic RNA, in a neuroblastoma clone, NBE-(A), after induction of differentiation by 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone, an inhibitor of adenosine 3',5'-monophosphate phosphodiesterase. The amount of RNA that contains polyadenylic acid in cytoplasm may be greater in such differentiated neuroblastoma cells than in proliferating control cells.

• Authors: S C Bondy, K N Prasad, J L Purdy
• Journal: Science (New York, N.Y.) (Science) Vol. 186 Issue 4161 Pg. 359-61 (Oct 25 1974) ISSN: 0036-8075 [Print] United States
• PMID: 4370218 (Publication Type: Journal Article)

Chemical References

• Benzyl Compounds
• Culture Media
• Ethers
• Imidazoles
• Phosphodiesterase Inhibitors
• Polynucleotides
• RNA, Neoplasm
• RNA, Ribosomal
• Tritium
• Adenosine Monophosphate
• Cyclic AMP
• Acetyltransferases
• Adenosine
• Choline

Topics

• Acetyltransferases (metabolism)
• Adenosine (metabolism)
• Adenosine Monophosphate (biosynthesis, metabolism)
• Animals
• Benzyl Compounds (pharmacology)
• Brain (cytology)
• Cell Differentiation (drug effects)
• Chickens
• Choline
• Clone Cells (metabolism)
• Culture Media
• Cyclic AMP
• Cytoplasm (metabolism)
• Ethers (pharmacology)
• Imidazoles (pharmacology)
• Microscopy, Phase-Contrast
• Neuroblastoma (metabolism, pathology)
• Phosphodiesterase Inhibitors
• Polynucleotides (metabolism)
• RNA, Neoplasm (biosynthesis, metabolism)
• RNA, Ribosomal (metabolism)
• Tritium