Hemopoietic colony-forming cell responses in mice infected with ectromelia virus.

Abstract

The responses of in vitro colony-forming cells (granulocyte-macrophage progenitor cells) were studied in the bone marrow, spleen, and blood of mice after intraperitoneal injection of 10(3) plaque-forming units of ectromelia virus. This study showed that a colony-forming cell response occurred during infection and was accompanied by an increase in the serum level of colony-stimulating factor and, at a later stage, colony-inhibiting factor. Changes in the proportions of colony-forming cells were not due to relative changes in other cell populations. The relationships between colony-forming cell responses and levels of infection were complex, higher levels of infection being associated with good colony-forming cell responses in bone marrow and apparently poor colony-forming cell responses in blood and spleen.

• Authors: T A McNeill, M Killen
• Journal: Infection and immunity (Infect Immun) Vol. 4 Issue 4 Pg. 323-30 (Oct 1971) ISSN: 0019-9567 [Print] United States
• PMID: 4343405 (Publication Type: Journal Article)

Chemical References

• Interferons

Topics

• Animals
• Bone Marrow (immunology)
• Bone Marrow Cells
• Cell Division
• Clone Cells (immunology)
• Ectromelia virus (growth & development, immunology)
• Female
• Interferons
• L Cells (immunology)
• Leukocyte Count
• Leukocytes (immunology)
• Macrophages (immunology)
• Male
• Mice
• Mice, Inbred Strains
• Poxviridae Infections (immunology)
• Spleen (immunology)
• Time Factors