Acetoxycycloheximide-induced transient amnesia: protective effects of adrenergic stimulants.

Abstract

It has previously been shown that rats trained 5 hr after intracerebral injection of acetoxycycloheximide show a transient amnesia at 24 hr after training. We have tested the possibility that adrenergic stimulants might provide protection from the amnesia. Metaraminol, given either before or after training or before testing, prevents the drug-induced amnesia. D-Amphetamine, injected soon after training, also prevents the amnesia. A model is presented to explain the drug-induced amnesia in terms of both the assumed effect of acetoxycycloheximide on the adrenergic system and prevention of the amnesia by metaraminol and D-amphetamine.

• Authors: R G Serota, R B Roberts, L B Flexner
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 69 Issue 2 Pg. 340-2 (Feb 1972) ISSN: 0027-8424 [Print] United States
• PMID: 4333977 (Publication Type: Journal Article)

Chemical References

• Acetates
• Metaraminol
• Cycloheximide
• Amphetamine
• Norepinephrine

Topics

• Acetates (pharmacology)
• Amnesia (chemically induced, prevention & control)
• Amphetamine (therapeutic use)
• Animals
• Avoidance Learning (drug effects)
• Cycloheximide (pharmacology)
• Discrimination Learning (drug effects)
• Humans
• Male
• Metaraminol (therapeutic use)
• Norepinephrine (physiology)
• Rats
• Rats, Inbred Strains
• Synaptic Transmission (drug effects)