[Haemodynamic effects of depot zinc protamine glucagon in heart failure (author's transl)].

Abstract

In contrast to intravenously-administered crystallene glucagon, which acts for 20 minutes only, the depot form, zinc protamine glucagon, shows a prolonged haemodynamic action. Fourteen patients with pre-existing heart failure received a single dose of 20 mg Zn protamine glucagon intramuscularly. The stroke volume and cardiac output were increased, whereas the mean and end-diastolic pulmonary pressure were decreased, indicating a positive inotropic action of the administered drug. Heart rate and mean arterial pressure remained almost unchanged. The haemodynamic changes started 60 minutes after intramuscular administration of the drug, reached a maximum effect at 3 hours and started to decrease after the fourth hour. Zn protamine glucagon can, therefore, be considered a beneficial drug in the treatment of digitalis-resistant heart failure on the basis of its long duration of action and easy route of administration.

• Authors: M Pichler, G Kleinberger, H Lochs, D Magometschnigg, H Pall
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 91 Issue 2 Pg. 49-51 (Jan 19 1979) ISSN: 0043-5325 [Print] Austria
• Vernacular Title: Hämodynamische Wirkungen von Depot-Zink-Protamin-Glukagon bei kardialer Dekompensation.
• PMID: 433280 (Publication Type: English Abstract, Journal Article)

Chemical References

• Delayed-Action Preparations
• Glucagon

Topics

• Aged
• Blood Pressure (drug effects)
• Delayed-Action Preparations
• Female
• Glucagon (therapeutic use)
• Heart Failure (drug therapy)
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged
• Pulmonary Circulation (drug effects)
• Stroke Volume (drug effects)
• Vascular Resistance (drug effects)