Combined therapy of leukemia La with Damvar and cytostatics.

Abstract	The new cytostatic drug Damvar, delta-(2-amino-6-hydroxy-3,4-dihydro-4-oxo-5-pyrimidinyl)valeric acid, is not effective in La leukemia system. Damvar given in combination with 5-fluorouracil enhanced the anti-La effect of 5-Fu. There was also enhancement of the antileukemic effect of suboptimal and optimal doses of cyclophosphamide with the addition of Damvar.
Authors	V Pujman, S Cernochová
Journal	Neoplasma (Neoplasma) Vol. 26 Issue 1 Pg. 85-8 ( 1979) ISSN: 0028-2685 [Print] Slovakia
PMID	431759 (Publication Type: Journal Article)
Chemical References	Antimetabolites, Antineoplastic Pyrimidines Pyrimidinones damvar Cyclophosphamide Fluorouracil
Topics	Animals Antimetabolites, Antineoplastic (administration & dosage) Cyclophosphamide (administration & dosage) Drug Synergism Drug Therapy, Combination Fluorouracil (administration & dosage) Leukemia, Experimental (drug therapy) Male Mice Mice, Inbred C57BL Pyrimidines (administration & dosage) Pyrimidinones

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