The effect of an interferon inducer on influenza virus.

Abstract

The double-stranded complex of polyriboinosinic acid and polyribocytidilic acid (poly I.poly C) was shown to inhibit effectively the infection of human cells with 4 common human respiratory pathogens-influenza A2, rhinovirus 13, respiratory syncytial and parainfluenza-1 viruses. This protection was observed with levels of poly I.poly C which did not induce the release of detectable amounts of interferon. Mice could be protected from pulmonary influenza A2 infections by intranasal instillation of poly I.poly C before challenge with virus. Administration of poly I.poly C directly to the respiratory tract was found superior to systemic administration in the case of the pulmonary infection studied.

• Authors: D A Hill, S Baron, R M Chanock
• Journal: Bulletin of the World Health Organization (Bull World Health Organ) Vol. 41 Issue 3 Pg. 689-93 ( 1969) ISSN: 0042-9686 [Print] Switzerland
• PMID: 4314307 (Publication Type: Journal Article)

Chemical References

• Cytosine Nucleotides
• Nucleosides
• Polynucleotides
• Interferons

Topics

• Animals
• Culture Techniques
• Cytosine Nucleotides (pharmacology)
• Humans
• Influenza, Human (prevention & control)
• Interferons (biosynthesis)
• Mice
• Nucleosides (pharmacology)
• Orthomyxoviridae (drug effects)
• Polynucleotides (pharmacology)
• Rhinovirus (drug effects)