Presence of particles other than the Australia-SH antigen in a case of chronic active hepatitis with cirrhosis.

Abstract	Examination of serum specimens from a patient with chronic active hepatitis proved negative to the Australia-SH antigen by immunodiffusion and by complement fixation. Because the sera were anticomplementary they were examined with the electron microscope, and virus-like structures similar to members of the coronavirus group were identified. The possible significance of this finding in human serum and its relation to mouse hepatitis virus are discussed.A sample of the serum pool containing the MS-1 agent was found negative when examined by immunodiffusion, complement fixation, and electron microscopy. The possible lack of immunological identity between infectious and serum hepatitis is discussed.
Authors	A J Zuckerman, P E Taylor, J D Almeida
Journal	British medical journal (Br Med J) Vol. 1 Issue 5691 Pg. 262-4 (Jan 31 1970) ISSN: 0007-1447 [Print] England
PMID	4313591 (Publication Type: Journal Article)
Chemical References	Hepatitis B Antigens
Topics	Complement Fixation Tests Hepatitis A (complications, immunology, microbiology) Hepatitis B (immunology) Hepatitis B Antigens Hepatitis B virus Humans Immunodiffusion Liver Cirrhosis (complications, microbiology) Male Microscopy, Electron Middle Aged Murine hepatitis virus

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!