Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.

Abstract

The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.

• Authors: W J Ross, R G Harrison, M R Jolley, M C Neville, A Todd, J P Verge, W Dawson, W J Sweatman
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 22 Issue 4 Pg. 412-7 (Apr 1979) ISSN: 0022-2623 [Print] United States
• PMID: 430478 (Publication Type: Journal Article)

Chemical References

• Oxazoles
• SRS-A

Topics

• Anaphylaxis (drug therapy)
• Animals
• Bronchial Spasm (immunology, prevention & control)
• Capillary Permeability (drug effects)
• Female
• Guinea Pigs
• Humans
• In Vitro Techniques
• Lung (drug effects, immunology)
• Male
• Oxazoles (chemical synthesis, pharmacology)
• Passive Cutaneous Anaphylaxis (drug effects)
• Rats
• SRS-A (metabolism)
• Structure-Activity Relationship