Treatment of gonorrheal urethritis with spectinomycin hydrochloride.

Abstract

One hundred and eighty-seven males with uncomplicated gonorrheal urethritis were treated with spectinomycin hydrochloride in a dosage of 2 g. given intramuscularly. A failure rate of 3.2% was observed and no complications of therapy were encountered. In addition, 310 strains of N. gonorrhoeae were tested for susceptibility to penicillin G and spectinomycin. All strains were sensitive to 20 mug./ml. of spectinomycin and this susceptibility appeared to decrease as penicillin resistance increased. A greater incidence of relative resistance to penicillin G was observed than in similar studies from other Canadian areas.

• Authors: J Brown, O Tabert, J D Hanna, P L Rentiers
• Journal: Canadian Medical Association journal (Can Med Assoc J) Vol. 110 Issue 2 Pg. 173 passim (Jan 19 1974) ISSN: 0008-4409 [Print] Canada
• PMID: 4272505 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Spectinomycin
• Penicillin G

Topics

• Evaluation Studies as Topic
• Follow-Up Studies
• Gonorrhea (drug therapy)
• Humans
• Male
• Microbial Sensitivity Tests
• Neisseria gonorrhoeae (drug effects, isolation & purification)
• Penicillin G (pharmacology)
• Penicillin Resistance
• Spectinomycin (pharmacology, therapeutic use)
• Urethra (microbiology)
• Urethritis (drug therapy)