[Plasmaperfusion through activated charcoal and amberlite XAD-7 in dogs with liver failure induced by yellow phosphorus (author's transl)].

Abstract

Various sorbents were tested in-vitro for their ability to support hepatic excretory and detoxification functions, and their in-vivo perfusion with plasma was studied in an animal experiment. Amino acids, particularly phenylalanine and tyrosine, were strongest bound by activated charcoal, while Amberlite XAD-7 removed conjugated and unconjugated bilirubin and bile acids from plasma. Using a cell-separator plasma of dogs, in whom acute liver failure was induced by yellow phosphorus, was perfused through a combination of charcoal and Amberlite XAD-7 without major complications. Platelet counts remained nearly unchanged, platelet aggregation was inhibited reversibly, and circulating platelet aggregates occurred late only. It is concluded that using the method described, therapeutic trials in patients with fulminant hepatic failure can be performed.

• Authors: W Horak, P Polterauer, F Renner, K Silberbauer, R Rauhs, F Mühlbacher, J Funovics
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 17 Issue 2 Pg. 90-8 (Feb 1979) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Plasmaperfusion über Aktivkohle und Amberlite XAD-7 bei der phosphor-induzierten Lebernekrose des Hundes.
• PMID: 425590 (Publication Type: English Abstract, Journal Article)

Chemical References

• Bile Acids and Salts
• Resins, Plant
• Charcoal
• Phosphorus
• Bilirubin

Topics

• Animals
• Bile Acids and Salts (isolation & purification)
• Bilirubin (isolation & purification)
• Charcoal
• Dogs
• Hemoperfusion (instrumentation)
• Liver Cirrhosis (chemically induced, therapy)
• Phosphorus
• Resins, Plant