Pharmacokinetics of fazadinium in patients with renal failure.

Abstract

The serum concentrations of fazadinium and its metabolites were measured in 14 surgical patients with end-stage renal failure and in 11 patients free from kidney disease undergoing abdominal surgery. A two-compartment open model was used in the pharmacokinetic analysis of the data. The elimination half-life (T 1/2 beta) was prolonged by 60% in patients with renal failure (from 85 to 140 min) and corresponded to a 30% decrease of the plasma clearance. The plasma concentration of the metabolites never exceeded 7% of the unchanged fazadinium. These results suggest that the duration of action will be less prolonged for fazadinium than for other non-depolarizing neuromuscular blocking drugs in patients with renal failure. A supplementary biliary pathway appears to be a possible explanation for the rapid elimination of fazadinium, even in patients with renal failure.

• Authors: P Duvaldestin, J C Bertrand, D Concina, D Henzel, L Lareng, J M Desmonts
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 51 Issue 10 Pg. 943-7 (Oct 1979) ISSN: 0007-0912 [Print] England
• PMID: 42420 (Publication Type: Journal Article)

Chemical References

• Pyridinium Compounds

Topics

• Adult
• Female
• Half-Life
• Humans
• Kidney Failure, Chronic (metabolism, surgery)
• Kinetics
• Male
• Middle Aged
• Models, Biological
• Pyridinium Compounds (blood, metabolism)
• Surgical Procedures, Operative